{"created":"2023-06-19T09:40:21.288907+00:00","id":512,"links":{},"metadata":{"_buckets":{"deposit":"fc2264b3-1a06-4b24-a438-bc0381824593"},"_deposit":{"created_by":18,"id":"512","owners":[18],"pid":{"revision_id":0,"type":"depid","value":"512"},"status":"published"},"_oai":{"id":"oai:yasuda-u.repo.nii.ac.jp:00000512","sets":["7:58"]},"author_link":["1076","1074","398","1089","1090","1077","1075","1091","1092","1093"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"48","bibliographicPageEnd":"350","bibliographicPageStart":"339","bibliographic_titles":[{"bibliographic_title":"安田女子大学紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Journal of Yasuda Women's University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　Recently UHPLC, where smaller particle (2～3 μm) packing materials are employed, is progressing rapidly. Higher performance (higher theoretical plate number, lower theoretical plate height) and fast analysis can be obtained by the UHPLC, compared with the conventional HPLC with the usual size packing materials (5 μm). In this study, core-shell (CS) type packing materials (particle size 2.6 μm, column length 10 cm) are used for the separation of diltiazem (DIL), 8-chlorodilitiazem, and those related substances such as trans-form and deacetyl-form (DIL-OH). Four CS type reversed-phase columns, including a phenyl column and a phenylhexyl column both having a planar moiety, are investigated with the mobile phase containing acetonitrile as an organic solvent. Among four CS type columns, a Cholestyer column gave large Rs values for the separation between isomers such as cis-form (DIL) and its trans-form, n-propyl paraben and isopropyl paraben. On the other hand, separation of DIL and DIL-OH was successful by employing a phenyl column and a phenyl-hexyl column. For the separation of 8-chlorodilitiazem and its related substances, the tendency was the same as in DIL. Finally, assay and content uniformity testing of DIL formulations such as tablets and injections, purity testing (related substances) of DIL drug substances and formulations were successfully performed within 100 s, showing the usefulness of this type column as a tool of high through put analysis.","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24613/00000491","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"安田女子大学","subitem_publisher_language":"ja"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00242368","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0289-6494","subitem_source_identifier_type":"PISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西, 博行","creatorNameLang":"ja"},{"creatorName":"ニシ, ヒロユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川畑, 公平","creatorNameLang":"ja"},{"creatorName":"カワバタ, コウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"稲垣, 昌宣","creatorNameLang":"ja"},{"creatorName":"イナガキ, マサノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土井, 美歩","creatorNameLang":"ja"},{"creatorName":"ドイ, ミホ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤田, 侑里","creatorNameLang":"ja"},{"creatorName":"サワダ, ユリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishi, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawabata, Kohei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inagaki, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Doi, Miho","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawada, Yuri","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-19"}],"displaytype":"detail","filename":"02896494048035.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"02896494048035.pdf","url":"https://yasuda-u.repo.nii.ac.jp/record/512/files/02896494048035.pdf"},"version_id":"c55f1c77-3d96-4830-a466-a9fa99acc8e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Diltiazem","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"deacetyl-form","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HPLC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"core-shell type packing materials","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biphenyl column","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"平面性を有するコアシェル型逆相カラム-HPLCでのジルチアゼム類の分離選択性と迅速製剤分析法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"平面性を有するコアシェル型逆相カラム-HPLCでのジルチアゼム類の分離選択性と迅速製剤分析法の開発","subitem_title_language":"ja"},{"subitem_title":"Selectivity in the Separation of Diltiazem and its Related Substances by HPLC with Core-shell Type Reversed-phase Columns Having a Planar Moiety and Development of a Fast Analysis of Diltiazem Formulations","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"18","path":["58"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-03-19"},"publish_date":"2020-03-19","publish_status":"0","recid":"512","relation_version_is_last":true,"title":["平面性を有するコアシェル型逆相カラム-HPLCでのジルチアゼム類の分離選択性と迅速製剤分析法の開発"],"weko_creator_id":"18","weko_shared_id":-1},"updated":"2024-01-31T04:04:18.673049+00:00"}